Endocrine Abstracts

Growth hormone (GH) is the major regulator of postnatal growth and an important metabolic regulator. It modulates a variety of processes in many tissues, ranging from adipogenesis to neurogenesis and immune function.GH is currently thought to activate its receptor through hormone-induced dimerization, resulting in activation of the Janus kinase, JAK2. However, we find that the receptor exists as a dimer in the plasma membrane before hormone binding, base...

Mike Waters, Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia AbstractProfessor Mike Waters is an NHMRC Principal Research Fellow at the Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland. Mike has been involved in the study of GH action for over 30 years. It was his pioneering work in purifying and characterizing the GH receptor, its related ...

Recent reports have raised concerns that dopamine agonist drugs, particularly cabergoline and pergolide, may be associated with cardiac valvulopathy. Dopamine agonists exert their prolactin-suppressive effect via lactotroph D2S receptors, while cardiac fibrosis appears to be mediated via 5HT2B receptors. We have assessed the receptor binding and functional effects of a range of dopamine agonists to determine their relative potencies at these two receptors...

Glucocorticoids (Gcs) act through the ubiquitously expressed glucocorticoid receptor (GR). Transcriptional activation by the GR involves interaction with co-modulator proteins, the expression level of which can mediate Gc sensitivity. The aim of this study was to identify additional GR interacting proteins that may influence Gc sensitivity.Using a yeast two-hybrid screen we identified a novel GR interacting protein, R59, which showed an enhanced interact...

Introduction: The ability to diagnose thyroid cancers pre-op or intra operatively by Fine needle aspiration cytology (FNAC) or frozen section (FS) leads to the delivery of appropriate one stage surgical management. We aim to study the concordance and discordance of FNAC and FS with final histology in thyroid pathologies.Methods: All thyroid procedures from 2007 to 2011 (n=423), involving FNAC and or Frozen Section (FS) in their management pathwa...

Glucocorticoids (Gcs) exert their pleiotropic effects through activation of the ubiquitously expressed glucocorticoid receptor (GR). The mechanism of transcriptional activation by the GR involves interaction with co-modulator proteins. Glucocorticoid sensitivity is mediated by the expression level of these co-modulator proteins and GR concentration. Therefore, the aim of this study was to identify additional GR interacting proteins that may influence glucocorticoid sensitivity...

(This poster is based on OC29)...

Growth hormone receptor (GHR) defective Laron Syndrome (LS) has been treated with daily subcutaneous recombinant insulin-like-growth factor 1 (IGF1) injections lasting many years. We have reported the results of treatment of 4-5 week old Laron dwarf mice (GHR-/-) with a single injection of an adeno-associated virus vector with a murine GHR (AAV-GHR) and a liver specific promoter at a dose of 4 × 1010 vector genome per mouse (Sia et al, Gene Therapy 202...

Background: The pathogenesis, biologic behavior, and treatment of well-differentiated neuroendocrine tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC) are different. The diagnosis relies on multiple factors, but pathologic assessment is crucial. Based on currently available diagnostic criteria, the distinction between NET G3 and NEC are made on morphologic assessment, without taking Ki-67 proliferative index into consideration. This study looks at the conc...